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| Localname | Intermediate | Product name | Structure | CAS NO | API to be made |
|---|---|---|---|---|---|
| 布瓦西坦中间体-1 Brivaracetam ITS-1 | (R)-4-丙基二氢呋喃-2(3H)-酮 | (R)-4-Propyldihydrofuran-2(3H)-one |  |
63095-51-2 | 布瓦西坦 Brivaracetam |
| 奥泽沙星中间体-2 Ozenoxacin ITS-2 | [6-[苯甲酰基(甲基)氨基]-5-甲基-3-吡啶]硼酸 | [6-[Benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid |  |
446299-81-6 | 奥泽沙星 Ozenoxacin |
| 奥泽沙星中间体-1 Ozenoxacin ITS-1 | 奥泽沙星中间体 | Ozenoxacin intermediate |  |
103877-38-9 | 奥泽沙星 Ozenoxacin |
| 立他司特中间体-3 Lifitegrast ITS-3 | 苯并呋喃-6-羧酸 | 6-Benzofurancarboxylic acid |  |
77095-51-3 | 立他司特 Lifitegrast |
| 立他司特中间体-2 Lifitegrast ITS-2 | \ | \ |  |
1194550-59-8 (R=Bn) 851785-21-2 (R=Me) 1270093-99-6 (R=H) | 立他司特 Lifitegrast |
| 立他司特中间体-1 Lifitegrast ITS-1 | \ | \ |  |
851784-82-2 (R1=H, R2=Boc) 851784-80-0(R1=Me, R2=Boc) 1289646-93-0 (R1=H, R2=H) 851784-90-2 (R1=Me, R2=H) | 立他司特 Lifitegrast |
| 帕博西尼 Palbociclib base | 帕博西尼 | palbociclib |  |
571190-30-2 | 帕博西林盐酸盐Palbociclib Hydrochloride |
| 帕博西林中间体-3 Palbociclib ITS-3 | \ | \ |  |
866084-31-3(R=n-Butyl) 571189-10-1(R=Ethyl) | 帕博西林盐酸盐Palbociclib Hydrochloride |
| 帕博西林中间体-2 Palbociclib ITS-2 | 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯 | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate |  |
571188-59-5 | 帕博西林盐酸盐Palbociclib Hydrochloride |
| 帕博西林中间体-1 Palbociclib ITS-1 | 6-溴-2-氯-8-环戊基-5-甲基-吡啶并[2,3-D]嘧啶-7(8H)-酮 | 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one |  |
1016636-76-2 | 帕博西林盐酸盐Palbociclib Hydrochloride |
| 克立硼罗中间体-3 Crisaborole ITS-3 | 4-[4-溴-3-(羟基甲基)苯氧基]苯甲腈 | 4-(4-broMo-3-(hydroxyMethyl)phenoxy)benzonitrile |  |
906673-45-8 | 克立硼罗 Crisaborole |
| 克立硼罗中间体-2 Crisaborole ITS-2 | 4-(4-溴-3-甲酰基苯氧基)苯甲腈 | 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile |  |
906673-54-9 | 克立硼罗 Crisaborole |
| 克立硼罗中间体-1 Crisaborole ITS-1 | 2-溴-5-羟基苯甲醛 | 2-BROMO-5-HYDROXYBENZALDEHYDE |  |
2973-80-0 | 克立硼罗 Crisaborole |
| 卡培他滨中间体Cap-6 Capecitabine ITS Cap-6 | 5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯 | 5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate |  |
162204-20-8 | 卡培他滨 Capecitabine |
| 卡培他滨中间体Cap-5 Capecitabine ITS Cap-5 | 2',3'-二-O-乙酰基-5'-脱氧-5-氟-D-胞啶 | 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine |  |
161599-46-8 | 卡培他滨 Capecitabine |
| 卡培他滨中间体Cap-4 Capecitabine ITS Cap-4 | 1,2,3-三乙酰氧基-5-脱氧-D-核糖 | 1,2,3-Triacetyl-5-deoxy-D-ribose |  |
62211-93-2 | 卡培他滨 Capecitabine |
| 吉西他滨中间体-T9 Gemcitabine ITS-T9 | 2',2'-二氟-2'-脱氧胞嘧啶核苷-3',5'-二苯甲酸酯 | 2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate |  |
134790-39-9 | 吉西他滨 Gemcitabine |
| 吉西他滨中间体-T8 Gemcitabine ITS-T8 | 2-脱氧-2,2-二氟-D-赤式-五呋喃糖-3,5-二苯甲酯-1-甲磺酸酯 | 2-deoxy-2,2-difluoro-d-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate |  |
122111-11-9 | 吉西他滨 Gemcitabine |
| 吉西他滨中间体-T6 Gemcitabine ITS-T6 | 2-脱氧-2,2-二氟戊呋喃糖-1-酮 3,5-二安息香酸盐 | 2-Deoxy-2,2-difluoro-D-erythropentofuranose-3,5-dibenzoate |  |
122111-01-7 | 吉西他滨 Gemcitabine |
| 伏立康唑中间体-5 Voriconazole ITS-5 | 伏立康唑樟脑磺酸盐 | 2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate |  |
137234-71-0 | 伏立康唑 Voriconazole |
| 伏立康唑中间体-4 Voriconazole ITS-4 | (2R,3S/2S,3R)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑- 1-基)-2-丁醇 | (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol |  |
188416-29-7 | 伏立康唑 Voriconazole |
| 伏立康唑中间体-3 Voriconazole ITS-3 | 3-(6-氯-5-氟嘧啶-4-基)-2-(2 4-二氟苯基)-1-(1H-1 4-三唑-1-基)-2-丁醇盐酸盐 | 3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride salt |  |
188416-20-8 or 188416-35-5 | 伏立康唑 Voriconazole |
| 伏立康唑中间体-2 Voriconazole ITS-2 | 2,4-二氟-2-1(1氢-1,2,4-三氮唑1-基)苯乙酮 | 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone |  |
86404-63-9 | 伏立康唑 Voriconazole |
| 伏立康唑中间体-1 Voriconazole ITS-1 | 4-氯-6-乙基-5-氟嘧啶 | 4-Chloro-6-ethyl-5-fluoropyrimidine |  |
137234-74-3 | 伏立康唑 Voriconazole |
| AZ-4 | 3,3-二氨基-2-丙烯酸-N-二苯甲基氮杂-3-丁酯乙酸盐 | crystal 2-propenoic acid, 3,3-diamino-1- (diphenylmethyl)-3-azetidinyl ester Monoacetate |  |
221906-67-8 | 阿折地平 Azelnidipine |
